In Celebration of Medical Misfits
Had bumper stickers existed in the 1850s, Dr. John Snow might have had one on the back of his carriage that later became popular in the 1960s with the counterculture crowd that read:
Subvert the Dominant Paradigm
It was 1854, and a deadly cholera outbreak was tearing through London. At the time, the medical establishment believed cholera spread through miasma—a poisonous cloud of bad air.
John Snow, an unknown physician who lived in the affected neighborhood, saw something different. As he watched neighbors die, he became convinced the disease wasn’t airborne—it was waterborne.
When Snow presented his theory to London’s medical leaders, he was dismissed. But he persisted. Through interviews, careful observation, data tables, and his now-famous map, Snow traced the outbreak to a contaminated water pump. His work helped stop the epidemic—and gave rise to what we now call epidemiology.
Healthcare has been here before.
Fast-forward to the 1970s. Even with mounting evidence, endoscopic surgery faced strong resistance. Leading surgeons believed “large problems required large incisions.” Minimally invasive “keyhole” surgery was dismissed.
Today, endoscopy is recognized as one of the most important breakthroughs in modern medicine.
Change is hard—especially in healthcare.
Since medicine emerged as a data-driven scientific discipline, progress has depended on leaders willing to challenge prevailing assumptions. Vaccines. Antibiotics. Sanitation. Clean water. Preventive care. None of these advances came from doing more of the same.
Standing behind every major leap forward were leaders who shared two traits:
- They saw problems through a different lens.
- They were willing to challenge the status quo to make healthcare better.
To be clear: thinking differently does not mean ignoring evidence or freestyling in the operating room. Medicine depends on rigor, standards, and proven best practices. But progress happens when we apply that science in new ways—more inclusive, more efficient, and more effective ways.
The art and science of thinking differently
Steve Jobs famously made “Think Different” a rallying cry, reminding us that the people who change the world are often the ones who see it differently.
True innovators connect the unconnected. They combine ideas across disciplines. They don’t just play the game better—they change the game.
Yet not all leaders are equal when it comes to innovation. Research shows that successful innovators spend significantly more time deliberately trying to think differently. For many people, this doesn’t come naturally—and it can feel uncomfortable or exhausting.
The good news? Thinking differently is a skill, not a gift. Most of our innovation capacity is shaped by environment and practice, not genetics. With repetition, what once felt uncomfortable becomes energizing—and that’s when the best ideas emerge.
History is full of reminders that even breakthrough ideas take time to find their true purpose. Early visions for the telephone included using it merely to notify people that a telegraph message had arrived.
And now, here we are—with AI.
AI has exploded into healthcare and society, driving change at a pace few organizations are prepared for. What works today will feel outdated tomorrow. Leaders who are complacent with the current state of healthcare will be eclipsed by those who think differently, plan creatively, and act with intent.
While many health leaders talk about innovating with AI, I’m looking for the misfits—the ones whose ideas make traditionalists uneasy, but who ultimately move health and medicine forward.
They’re the ones who’ve always changed the world. Could that be you?
T.









